| Bioactivity | ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1]. | ||||||||||||
| Target | IC50: 0.37 μM (T. brucei PFK).IC50: 0.13 μM (T. cruzi PFK) | ||||||||||||
| Invitro | ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1]. Cell Cytotoxicity Assay[1] Cell Line: | ||||||||||||
| Name | ML251 | ||||||||||||
| CAS | 1486482-16-9 | ||||||||||||
| Formula | C17H13Cl2N3O4S | ||||||||||||
| Molar Mass | 426.27 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17. |
ML251
CAS: 1486482-16-9 F: C17H13Cl2N3O4S W: 426.27
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37
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