| Bioactivity | ML192 is a selective ligand antagonist of GPR55. ML192 inhibits the β-arrestin trafficking, ERK1/2 phosphorylation and PKCβII translocation[1]. | ||||||||||||
| Invitro | ML192 抑制 10 μM L-α 溶血磷脂酰肌醇 (LPI) 或 1 μM ML186 诱导的 β-arrestin 转运，IC50 值分别为 0.70μM、0.29 µM[1]。ML192 显著抑制表达 GPRSS 的 U2OS 细胞中 ERK1/2 的磷酸化[1]。ML192 (0, 10, 30 和 100 µM) 减弱了野生型 GPR55 受体细胞中的 PKCβII 易位[1]。 | ||||||||||||
| Name | ML192 | ||||||||||||
| CAS | 460331-61-7 | ||||||||||||
| Formula | C20H22N4O2S | ||||||||||||
| Molar Mass | 382.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Kotsikorou E, et al. Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands. Biochemistry. 2013 Dec 31;52(52):9456-69. |