| Bioactivity | ML 2-23 is a potent PROTAC BCR-ABL degrader. ML 2-23 is selectively degrade BCR-ABL in a proteasome-dependent manner in leukemia cells[1]. |
| Invitro | ML 2-23 (1 μM; 12 h; K562 细胞) 以蛋白酶体依赖性方式降解 BCR-ABL[1]。 Western Blot Analysis[1] Cell Line: |
| Name | ML 2-23 |
| Formula | C47H53BrCl2N10O7S |
| Molar Mass | 1052.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luo M, et, al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28(4):559-566.e15. |