| Bioactivity | ML 2-14 is a PROTAC for degrading BRD4, with C4 alkyl linker. ML 2-14 exerts degradation of BRD4 in 231MFP breast cancer cells[1]. |
| Invitro | 带有 C4 烷基接头的 ML 2-14 在 231MFP 乳腺癌细胞中显示出强烈降解 BRD4 的作用，对 BRD4 的长亚型和短亚型的 DC50 值分别为 36 和 14 nM[1 ]。 |
| Name | ML 2-14 |
| Formula | C40H38BrCl2N7O3S |
| Molar Mass | 847.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luo M, et al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021;28(4):559-566.e15. |