MK2-IN-5_product_DataBase

Bioactivity	MK2-IN-5 is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 targets the protein interaction domain in the MAPK pathway. MK2-IN-5 inhibits HSP25 and HSP27 phosphorylation[1][2][3].
Invitro	MK2-IN-5 (5-10 μM, 2 h) 抑制 TGF-b1 诱导的人瘢痕疙瘩成纤维细胞中结缔组织生长因子和 I 型胶原的表达[3]。 0 --> MK2-IN-5 相关抗体:
In Vivo	MK2-IN-5 (2 mg/kg Intraperitoneal injection, single dose) 降低呼吸机相关性肺损伤模型中 HSP25 的磷酸化[2]。 Animal Model:
Name	MK2-IN-5
CAS	474713-20-7
Sequence	Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala
Shortening	KKKALNRQLGVAA
Formula	C61H113N21O16
Molar Mass	1396.68
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480. [2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600. [3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539.

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