| Bioactivity | MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 acetate targets the protein interaction domain in the MAPK pathway. MK2-IN-5 acetate inhibits HSP25 and HSP27 phosphorylation[1][2][3]. | ||||||
| Invitro | MK2-IN-5 acetate (5-10 μM, 2 h) 抑制 TGF-b1 诱导的人瘢痕疙瘩成纤维细胞中结缔组织生长因子和 I 型胶原的表达[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MK2-IN-5 acetate 相关抗体: | ||||||
| In Vivo | MK2-IN-5 acetate (2 mg/kg Intraperitoneal injection, single dose) 降低呼吸机相关性肺损伤模型中 HSP25 的磷酸化[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||
| Sequence | Lys-Lys-Lys-Ala-Leu-Asn-Arg-Gln-Leu-Gly-Val-Ala-Ala | ||||||
| Shortening | KKKALNRQLGVAA | ||||||
| Formula | C61H113N21O16.xC2H4O2 | ||||||
| Molar Mass | 1396.68 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light, under nitrogen
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) |
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| Reference | [1]. Gaestel M, et al. Peptides as signaling inhibitors for mammalian MAP kinase cascades [J]. Current pharmaceutical design, 2009, 15(21): 2471-2480. [2]. Damarla M, et al. Mitogen activated protein kinase activated protein kinase 2 regulates actin polymerization and vascular leak in ventilator associated lung injury [J]. PloS one, 2009, 4(2): e4600. [3]. Lopes L B, et al. Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor [J]. Biochemical and biophysical research communications, 2009, 382(3): 535-539. |
MK2-IN-5 acetate
CAS: F: C61H113N21O16.xC2H4O2 W: 1396.68 (free base)
MK2-IN-5 (Hsp25 kinase inhibitor) acetate is a Mk2 pseudosubstrate (Ki= 8 μM). MK2-IN-5 acetate targets the protein int
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