| Bioactivity | MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration[1]. | ||||||||||||
| Target | Ki: 7.9 nM (OGA) | ||||||||||||
| In Vivo | MK-8719 has excellent intrinsic potency and selectivity, improved Papp, high CNS exposure, good pharmacokinetics, favorable metabolic stability, and robust pharmacodynamic response[1]. | ||||||||||||
| Name | MK-8719 | ||||||||||||
| CAS | 1382799-40-7 | ||||||||||||
| Formula | C9H14F2N2O3S | ||||||||||||
| Molar Mass | 268.28 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29. |
MK-8719
CAS: 1382799-40-7 F: C9H14F2N2O3S W: 268.28
MK-8719 is a highly potent and selective O-GlcNAcase (OGA) inhibitor (Ki=7.9 nM for hOGA) with excellent CNS penetration
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