| Bioactivity | MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfold but does not result in sustained reductions in blood renin activity (PRA). This study evaluated the antihypertensive efficacy of MK-8141 in hypertensive disease. Despite its effects on ir-AR, MK-8141 (ACT-077825) did not produce significant blood pressure-lowering effects in the absence of sustained PRA inhibition. |
| CAS | 903579-36-2 |
| Formula | C35H39Cl2N3O3 |
| Molar Mass | 620.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin InhibitorsJ. Med. Chem., 2009, 52 (12), pp 3689-3702 |
MK-8141
CAS: 903579-36-2 F: C35H39Cl2N3O3 W: 620.61
MK-8141 (ACT-077825) is a renin inhibitor that significantly increases levels of immunoreactive renin (ir-AR) by sevenfo
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