| Bioactivity | MK-4541 is an orally active and selective androgen receptor (AR) modulator. MK-4541 acts as an antagonist to inhibit 5α-reductase. MK-4541 inhibits proliferation and induces apoptosis in AR positive prostate cancer cells. MK-4541 significantly inhibited the growth of R3327-G prostate tumors in xenograft mouse model[1]. |
| In Vivo | MK-4541 (100 mg/kg; 每天1次，每周5次，持续5周) 抑制含 R-3327-G 细胞的无胸腺裸鼠前列腺肿瘤生长[1]。MK-4541 (100 mg/kg, 200 mg/kg; 每周5次，持续5周) 对精囊具有抗雄激素作用，降低完好男性的血浆睾酮浓度，并抑制 Ki67 表达[1]。MK-4541 (15 mg/kg, 50 mg/kg; 每周5次，持续8周) 导致成年阉割小鼠肌肉骨骼质量和功能的损失[1]。 Animal Model: |
| Name | MK-4541 |
| CAS | 796885-38-6 |
| Formula | C22H31F3N2O3 |
| Molar Mass | 428.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chisamore MJ, et al. A novel selective androgen receptor modulator (SARM) MK-4541 exerts anti-androgenic activity in the prostate cancer xenograft R-3327G and anabolic activity on skeletal muscle mass & function in castrated mice. J Steroid Biochem Mol Biol. 2016 Oct;163:88-97. |