| Bioactivity | MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins. |
| Invitro | MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG2 and also enhances the formation of the endoperoxide, PGH2, and other prostaglandins[1]. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta[2]. |
| In Vivo | MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs[1]. |
| Name | MK-447 |
| CAS | 58456-91-0 |
| Formula | C11H16INO |
| Molar Mass | 305.16 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Shriver DA, et al. The gastric antisecretory and antiulcer activity of MK-447, an enhancer of prostaglandin synthesis. Life Sci. 1980 Dec 22-29;27(25-26):2483-7. [2]. Harada Y, et al. Acceleration of endogeneous PGI2 generation from isolated rat aortae by MK-447. Jpn J Pharmacol. 1981 Oct;31(5):845-8. |