| Bioactivity | MK 436 (MK-0436) is a metabolite present in dog urine with antitrypanosomal activity, particularly against Trypanosoma cruzi , the pathogen that causes Chagas disease[1][2]. |
| CAS | 33450-08-7 |
| Formula | C11H14N4O3 |
| Molar Mass | 250.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. VandenHeuvel, et al. Identification of canine urinary metabolites of the antiprotozoal agent 3a, 4, 5, 6, 7, 7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1, 2-benzisoxazole. Journal of pharmaceutical sciences 69.11 (1980): 1288-1292. [2]. Jennings, et al. Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement. Transactions of the Royal Society of Tropical Medicine and Hygiene 77.5 (1983): 693-698. |