| Bioactivity | MK-3328 is a β-Amyloid PET ligand, which exhibits high binding potency with an IC50 of 10.5 nM. |
| Target | IC50: 10.5 nM (β-Amyloid) |
| Invitro | MK-3328 exhibits amyloid binding potency balanced with low levels of nonspecific binding[1]. |
| In Vivo | In vivo, [18F]MK-3328 demonstrates favorable kinetics, exhibiting high brain uptake and good washout in normal rhesus monkey positron emission tomography (PET) imaging studies[1]. |
| Name | MK-3328 |
| CAS | 1201323-97-8 |
| Formula | C14H9FN4O |
| Molar Mass | 268.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Harrison ST, et al. Synthesis and Evaluation of 5-Fluoro-2-aryloxazolo[5,4-b]pyridines as β-Amyloid PET Ligands and Identification of MK-3328. ACS Med Chem Lett. 2011 Apr 18;2(7):498-502. |