| Bioactivity | MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy[1][2]. |
| Invitro | MK-0731 (0.415-300 nM; 48 小时) 诱导 A2780 细胞凋亡，EC50 为 2.7 nM[1]。 MK-0731 对结合 hERG 通道的亲和力很小 (IC50=20.5 μM)[1]。 MK-0731 能够在细胞中诱导有丝分裂阻滞，IC50 为 19 nM[1]。 Apoptosis Analysis[1] Cell Line: |
| Name | MK-0731 |
| CAS | 845256-65-7 |
| Formula | C25H28F3N3O2 |
| Molar Mass | 459.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
MK-0731
CAS: 845256-65-7 F: C25H28F3N3O2 W: 459.50
MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM an
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