| Bioactivity | MJ04 is a selective inhibitor for Janus Kinase 3 (JAK 3) with an IC50 of 2.03 nM. MJ04 inhibits T cell differentation and inhibits the proinfammatory cytokines in Lipopolysaccharides (HY-D1056)‑induced macrophages. MJ04 exhibits good pharmacokinetic characters in mice, promotes hair growth in DHT-induced androgenetic alopecia (AGA) in athymic mice model, without significant toxicity (LD50 >2 g/kg)[1]. |
| CAS | 2099014-23-8 |
| Formula | C20H16FN5 |
| Molar Mass | 345.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hossain MM, et al., Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter. J Transl Med. 2024 Apr 18;22(1):370. |