| Bioactivity | MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. MIRA-1 has anticancer activity[1]. | ||||||||||||
| Invitro | MIRA-1 suppresses growth of Saos-2-His273 cells expressing mutant p53[1].MIRA-1 (25 μM; 48 hours) inhibits cell growth in a mutant p53-dependent manner[1].MIRA-1 (5 μM; 14 days) dramatically reduces the number of colonies formed by His273-expressing Saos-2 cells, but is much less efficient in inhibiting p53-null Saos-2 cells[1].MIRA-1 (10 μM; 48 hours) causes a substantial increase in the fraction of Saos-2 and Saos-2-His273 cells with a sub-G1 DNA content in the presence of mutant p53[1].MIRA-1 (5 and 10 μM; 24 hours) induces EGFP expression, MDM2 and Bax in SKOV-His175 cells[1]. Cell Proliferation Assay Cell Line: | ||||||||||||
| Name | MIRA-1 | ||||||||||||
| CAS | 72835-26-8 | ||||||||||||
| Formula | C8H9NO4 | ||||||||||||
| Molar Mass | 183.16 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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