MIPS-9922_product_DataBase

Bioactivity	MIPS-9922 is a potent and selective PI3Kβ inhibitor with an IC50 of 63 nM. MIPS-9922 inhibits PI3Kβ with >30-fold higher potency than PI3Kδ. MIPS-9922 blocks PI3K mediated activation of platelet glycoprotein αIIbβ3 activation and platelet adhesion in vitro. MIPS-9922 shows anti-platelet and anti-thrombotic activities[1].
Invitro	MIPS-9922 可有效抑制 ADP 诱导的洗涤性血小板聚集。MIPS-9922 还可抑制整合素 αIIbβ3 活化和 αIIbβ3 依赖性血小板在高剪切下粘附于固定的血管性血友病因子 (vWF)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MIPS-9922 相关抗体:
In Vivo	MIPS-9922 (2.5 mg/kg，颈静脉推注；一次) 可防止体内电解血栓小鼠模型中动脉血栓形成，而不会引起长时间出血或过度失血[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1416956-33-6
Formula	C28H31F2N9O2
Molar Mass	563.60
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhaohua Zheng, et al. Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922). Eur J Med Chem. 2016 Oct 21:122:339-351.

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