MIND4-17_product_DataBase

Bioactivity	MIND4-17 is a potent NRF2 activator that covalently modifies a C151 residue of Keap1. MIND4-17 disrupts Keap1-Nrf2 association, leading to Nrf2 protein stabilization and nuclear translocation. MIND4‐17 exerts potent antioxidant activity[1][2].
Invitro	MIND4-17（0.1-2 μM；24 小时）以浓度依赖性显着增加典型 ARE 基因 Nqo1、Hmox1、Srx1 的表达，并在较小程度上增加 Gclc[1]。MIND4-17（0.1-2 μM；24 小时）在 WT 和 HD 突变体 ST14A 细胞中显示浓度依赖性诱导 NQO1 和 GCLM 蛋白[1]。MIN4-17 (0.1-10 μM) 降低小胶质细胞中的 ROS 水平和氮中间产物的产生[1]。 RT-PCR[1] Cell Line:
In Vivo	MIND4-17（2 mg/kg；玻璃体内注射；一次）激活 Nrf2 信号并减轻小鼠光损伤引起的视网膜功能障碍[2]。 Animal Model:
Name	MIND4-17
CAS	345989-24-4
Formula	C20H15N5O3S
Molar Mass	405.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Luisa Quinti, et al. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. Cell Chem Biol. 2016 Jul 21;23(7):849-861. [2]. Nan Chen, et al. The Nrf2 activator MIND4-17 protects retinal ganglion cells from high glucose-induced oxidative injury. J Cell Physiol. 2020 Oct;235(10):7204-7213.

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