| Bioactivity | MI-136 is an inhibitor of the menin-MLL protein-protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23.6 nM. MI-136 shows to block AR signaling and has the potential for the study in castration-resistant tumors[1][2]. | ||||||||||||
| Invitro | MI-136 (0-20) exhibits IC50values of 5.59 μM, 7.15 μM, 5.37 μM and 19.76 μM in LNCaP, VCaP, 22rv1 and PNT2 cells[2]. Cell Proliferation Assay[2] Cell Line: | ||||||||||||
| Name | MI-136 | ||||||||||||
| CAS | 1628316-74-4 | ||||||||||||
| Formula | C23H21F3N6S | ||||||||||||
| Molar Mass | 470.51 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|