| Bioactivity | MI-1063 is an inhibitor for DMD-2, that blocks the MDM2-p53 interaction, and activates the tumor suppressor function of p53. MI-1063 inhibits the growth of cancer cell RS4-11 and MV4-11 with IC50 of 179 nM and 93 nM. MI-1063 can be used as target protein ligand in synthesis of PROTAC degrader MD-265 (HY-169327)[1]. |
| CAS | 1410737-39-1 |
| Formula | C30H32Cl2FN3O4 |
| Molar Mass | 588.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Aguilar A, et al., Discovery of MD-265: A Potent MDM2 Degrader That Achieves Complete Tumor Regression and Improves Long-Term Survival of Mice with Leukemia. J Med Chem. 2024 Nov 14;67(21):19503-19518. |
MI-1063
CAS: 1410737-39-1 F: C30H32Cl2FN3O4 W: 588.50
MI-1063 is an inhibitor for DMD-2, that blocks the MDM2-p53 interaction, and activates the tumor suppressor function of
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