| Bioactivity | MGCD-265 analog is a potent and oral active inhibitor of c-Met and VEGFR2 tyrosine kinases, with IC50s of 29 nM and 10 nM, respectively. MGCD-265 analog has significant antitumor activity[1]. | ||||||||||||
| Invitro | MGCD-265 analog inhibits A549 cells migration and DU145 cells scattering, with IC50s of 0.4 μM and 0.08 μM, respectively, in HGF-driven cell migration and scattering assays[1].MGCD-265 analog inhibits HUVEC ERK phosphorylation (IC50=0.03 μM) and HUVEC proliferation (IC50=0.006 μM) in VEGF-dependent cell-based assays[1]. | ||||||||||||
| Name | MGCD-265 analog | ||||||||||||
| CAS | 875337-44-3 | ||||||||||||
| Formula | C26H20FN5O2S2 | ||||||||||||
| Molar Mass | 517.60 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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MGCD-265 analog
CAS: 875337-44-3 F: C26H20FN5O2S2 W: 517.60
MGCD-265 analog is a potent and oral active inhibitor of c-Met and VEGFR2 tyrosine kinases, with IC50s of 29 nM and 10 n
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