| Bioactivity | MG-T-19 is an effective TIM-3 inhibitor that can suppress the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9. MG-T-19 can increase the production of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) in peripheral blood mononuclear cells (PBMCs) from healthy donors, and enhance the ability of PBMCs to inhibit the proliferation of Kasumi-1 cells (an acute myelogenous leukemia cell line)[1]. |
| CAS | 328540-44-9 |
| Formula | C18H8Br2ClF3N4O2S |
| Molar Mass | 596.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Abdel-Rahman S A, et al. Small molecules from antibody pharmacophores (SMAbPs) as a hit identification workflow for immune checkpoints[J]. Science Advances, 2024, 10(42): eadq5540. |
MG-T-19
CAS: 328540-44-9 F: C18H8Br2ClF3N4O2S W: 596.60
MG-T-19 is an effective TIM-3 inhibitor that can suppress the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9. MG-T
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