| Bioactivity | MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an IC50 of 2.3 nM for rSCD1[1]. | ||||||||||||
| Target | EC50: 2.3 nM (rSCD1) | ||||||||||||
| In Vivo | MF-438 exhibits an ED50 between 1 and 3 mg/kg in a mouse model[1]. | ||||||||||||
| Name | MF-438 | ||||||||||||
| CAS | 921605-87-0 | ||||||||||||
| Formula | C19H18F3N5OS | ||||||||||||
| Molar Mass | 421.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Léger S, et al. Synthesis and biological activity of a potent and orally bioavailable SCD inhibitor (MF-438). Bioorg Med Chem Lett. 2010 Jan 15;20(2):499-502. |