| Bioactivity | MEY-003 is an Autotaxin(ATX) inhibitor with EC50s of 460 nM and 1.09 μM for hATX-β and hATX-ɣ (analysis with LPC18:1). MEY-003 behaves as a non-competitive inhibitor with K iof 432 nM. MEY-003 can be used for targeted ATX-related disease research [1]. |
| Invitro | MEY-003 (10 μM, 30 min) 阻断 HeLa 细胞的 LPA 信号传导，并减少 LPA1 受体内吞[1]。MEY-003 (100 μM, 0-24 h) 对 HeLa 和 HEK293 细胞无细胞毒性作用[1]。 0 --> MEY-003 相关抗体: Cell Cytotoxicity Assay[1] Cell Line: |
| Name | MEY-003 |
| Formula | C22H23NO4 |
| Molar Mass | 365.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Eymery M C, et al. Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids [J]. European Journal of Medicinal Chemistry, 2023: 115944. |