| Bioactivity | METTL3-IN-3 (compound 11) is a polyheterocyclic compound, acts as METTL3 inhibitor[1]. |
| Target | METTL3 |
| Invitro | METTL3，即甲基转移酶样 3，是 N6-甲基腺苷 (m6A) 唯一的催化亚基。METTL3 参与真核 mRNA 中内部腺苷残基的转录后甲基化，形成 m6A。m6A 是最丰富的 mRNA 修饰，因此 METTL3 在多种癌症类型中发挥关键作用，或依赖于或不依赖于其 m6A RNA 甲基转移酶活性[2]。 |
| Name | METTL3-IN-3 |
| CAS | 2767003-71-2 |
| Formula | C26H28BrFN6O2 |
| Molar Mass | 555.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Blackaby WP, et al. Preparation of polyheterocyclic compounds as METTL3 inhibitors: World Intellectual Property Organization, WO2021111124[P]. 2021-06-10. [2]. Zeng C, et al. Roles of METTL3 in cancer: mechanisms and therapeutic targeting. J Hematol Oncol. 2020 Aug 27;13(1):117. |