MET kinase-IN-4_product_DataBase

Bioactivity	MET kinase-IN-4 is an orally active Met kinase inhibitor. MET kinase-IN-4 has potent Met kinase inhibitory activity with an IC50 value of 1.9 nM. MET kinase-IN-4 can be used for the research of cancer[1].
Target	IC50: 1.9 nM (Met); 4 nM (Flt-3); 27 nM (VEGFR-2)
Invitro	MET kinase-IN-4 (Compound 2) 具有有效的 Met 激酶抑制活性，IC50 值为 1.9 nM[1]。MET kinase-IN-4 抑制 Flt-3 和 VEGFR-2 激酶，IC50 值分别为 4 和 27 nM[1]。MET kinase-IN-4 (3 μM) 在人和小鼠肝微粒体中表现出良好的代谢稳定性[1]。
In Vivo	MET kinase-IN-4 (Compound 2) 在小鼠体内具有良好的药代动力学特征[1]。MET kinase-IN-4 在 GTL-16 人胃癌异种移植模型中表现出显著的体内抗肿瘤活性[1]。 Animal Model:
Name	MET kinase-IN-4
CAS	888719-03-7
Formula	C25H16F2N4O3
Molar Mass	458.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kyoung Soon Kim, et al. Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities. J Med Chem. 2008 Sep 11;51(17):5330-41.

PeptideDB