| Bioactivity | MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pKi value of 10.3[1]. |
| Name | MEN 11270 |
| CAS | 235082-52-7 |
| Sequence | {d-Arg}-Arg-Pro-{Hyp}-Gly-{Thi}-c({Dab}-{d-Tic}-{Oic}-Arg)c(7γ-10α) |
| Shortening | {d-Arg}-RP-{Hyp}-G-{Thi}-c({Dab}-{d-Tic}-{Oic}-R)c(7γ-10α) |
| Formula | C60H90N20O11S |
| Molar Mass | 1299.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Meini S, et, al. MEN 11270, A novel selective constrained peptide antagonist with high affinity at the human B2 kinin receptor. J Pharmacol Exp Ther. 1999 Jun;289(3):1250-6. |
MEN 11270
CAS: 235082-52-7 F: C60H90N20O11S W: 1299.55
MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin r
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