| Bioactivity | MDP1, a Melittin-derived peptide, alters the integrity of both Gram-positive and Gram-negative bacterial membranes and kills the bacteria via membrane damages. MDP1 has a high-antibacterial activity against multidrug resistant (MDR) and reference strains of S. aureus, E. coli, and P. aeruginosa[1]. |
| Invitro | MDP1 exhibits more potent antibacterial activities against S. aureus, E. coli and P. aeruginosa. Geometric means of MICs for MDP1 is recorded at 4.06 μg/mL (S. aureus), 1.22 μg/mL (E. coli) and 3.75 μg/mL (P. aeruginosa), respectively[1].DNA and calcein release and flow cytometry assays indicate a time-dependent antibacterial activity on the examined bacteria affected by MDP1 (10, 5, 2.5, 1.25, 0.625 and 0.312 μg/mL). Finally, SEM analyses highlights dose- and time-dependent effects of MDP1 on S. aureus and E. coli bacteria by induction of vesicle or pore formation as well as cell lysis[1]. |
| Name | MDP1 |
| Shortening | GIGAVLKVLTTGLPALIKRKRQQ |
| Formula | C111H202N34O28 |
| Molar Mass | 2461.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |