| Bioactivity | MDM2-p53-IN-15 is a MDM2-p53 inhibitor with an IC50 value of 26.1 nM. MDM2-p53-IN-15 inhibits the proliferation of various cancer cells and induces cell apoptosis. MDM2-p53-IN-15 can be used for the research of cancer[1]. |
| Target | IC50: 26.1 nM (MDM2-p53) |
| Invitro | MDM2-p53-IN-15 (1–100 μM; 48 h) inhibits HCT116 cells proliferation[1].MDM2-p53-IN-15 (10-20 μM; 72-96 h) affects SJSA-1, LNCaP and MCF-7 proliferation[1].MDM2-p53-IN-15 (10-15 μM; 96 h) affects cell death and apoptosis in SJSA1 cells[1].MDM2-p53-IN-15 (0-1 μM; 1 h 30 min) dissociates MDM2-p53 complexes[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | MDM2-p53-IN-15 |
| Formula | C38H26Cl2N6O3 |
| Molar Mass | 685.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Espadinha M, et al. Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors. Eur J Med Chem. 2022 Aug 5;241:114637. |