MDL 72527 dihydrochloride_product_DataBase

Bioactivity	MDL 72527 dihydrochloride is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 dihydrochloride shows a lysosomotropic effect. MDL 72527 dihydrochloride shows neuroprotective effects[1][2].
Target	polyamine oxidase (PAO)
Invitro	MDL 72527 dihydrochloride (300 µM; 24 h) 在 M14 WT 细胞中出现明显的形态学变化，出现大量溶酶体和大量细胞质空泡[2]。 Cell Cytotoxicity Assay[2] Cell Line:
In Vivo	MDL 72527 dihydrochloride (100 mg/kg; i.p.; once) 对暂时性局灶性脑缺血后的神经元细胞损伤具有神经保护作用[1]。 Animal Model:
Name	MDL 72527 dihydrochloride
CAS	93565-01-6
Formula	C12H22Cl2N2
Molar Mass	265.22
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Reference	[1]. Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72(2):765-70. [2]. Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763(10):1040-50.

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