| Bioactivity | MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a Ki value of 25 nM. MDL 101146 can be used for the research of arthritis[1][2]. |
| Target | Ki for neutrophil elastase: 25 nM (human); 18 nM (rat) |
| Invitro | MDL 101,146 inhibits human neutrophil elastase with a Ki value of 25 nM[1].MDL 101,146 inhibits rat neutrophil elastase activity in a dose-related manner with a Ki value of 18 nM[2]. |
| In Vivo | MDL 101146 (oral, 200 mg/kg/day) significantly inhibits swelling and joint destruction in collagen-induced arthritis but not in adjuvant arthritis[2]. Animal Model: |
| Name | MDL 101146 |
| CAS | 149859-17-6 |
| Formula | C29H37F5N4O6 |
| Molar Mass | 632.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Angelastro M, et al. Inhibition of human neutrophil elastase with peptidyl [2]. M J Janusz, et al. Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146. Inflamm Res. 1997 Dec;46(12):503-8. |
MDL 101146
CAS: 149859-17-6 F: C29H37F5N4O6 W: 632.62
MDL 101146 is an orally active neutrophil elastase inhibitor. MDL 101146 inhibits neutrophil elastase for human with a K
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This product is for research use only, not for human use. We do not sell to patients.