| Bioactivity | MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1]. | ||||||||||||
| Target | MD2-TLR4. | ||||||||||||
| Name | MD2-TLR4-IN-1 | ||||||||||||
| CAS | 2249801-12-3 | ||||||||||||
| Formula | C22H14Cl2N4O | ||||||||||||
| Molar Mass | 421.28 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469. |
MD2-TLR4-IN-1
CAS: 2249801-12-3 F: C22H14Cl2N4O W: 421.28
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) comple
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