| Bioactivity | MD102 is a potent TG2 inhibitor with an IC50 value of 0.35 μM. MD102 stabilizes p53 by inhibiting TG2, inducing a decrease in p-AKT and p-mTOR downstream signaling, leading to tumor cell apoptosis[1]. |
| Name | MD102 |
| CAS | 2755794-94-4 |
| Formula | C13H4BrCl2FN2O2 |
| Molar Mass | 389.99 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim GR, et al. Discovery of novel 1H-benzo[d]imidazole-4,7-dione based transglutaminase 2 inhibitors as p53 stabilizing anticancer agents in renal cell carcinoma. Bioorg Chem. 2023 Dec 25;143:107061. |
MD102
CAS: 2755794-94-4 F: C13H4BrCl2FN2O2 W: 389.99
MD102 is a potent TG2 inhibitor with an IC50 value of 0.35 μM. MD102 stabilizes p53 by inhibiting TG2, inducing a decre
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