| Bioactivity | MCI alleviates inflammation by macrophage reprogramming via targeting ROS scavenging and COX-2 downregulation. MCI inhibits COX-2 with an IC50 value of 1.23 μM. MCI has significant anti-inflammatory effects in collagen-induced arthritis (CIA) models. MCI can be used in research for rheumatoid arthritis (RA)[1]. |
| Invitro | MCI (8 μM， 2 h) 在 LPS 刺激的 RAW 264.7 细胞中抑制 ROS 的产生和 COX-2 的表达，进而诱导巨噬细胞从 M1 型转向 M2 型[1]。 Immunofluorescence[1] Cell Line: |
| In Vivo | MCI (1.05 mg/kg， 关节内注射， 每三天一次， 持续 18 天) 可预防 RA 的进展，并具有显著的抗炎作用[1]。 Animal Model: |
| Name | MCI |
| Formula | C45H52ClN7O13 |
| Molar Mass | 934.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luo X, et al. Macrophage Reprogramming via Targeted ROS Scavenging and COX-2 Downregulation for Alleviating Inflammation. Bioconjug Chem. 2023 Jul 19;34(7):1316-1326. |