| Bioactivity | MCHR1 antagonist 4 (Compound 2m) is a blood-brain barrier permeable MCHR1 antagonist with Ki values of 0.74 nM and 0.76 nM for hMCHR1 and rMCHR1, respectively. MCHR1 antagonist 4 is also an effective anti-obesity agent[1]. |
| Target | Ki=0.74 nM (hMCHR1). Ki=0.76 nM (rMCHR1). |
| CAS | 1574538-43-4 |
| Formula | C26H30N2O4 |
| Molar Mass | 434.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yoon D S, et al. Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2, 4-dihydro-3 H-1, 2, 4-triazole-3-thione[J]. Journal of Medicinal Chemistry, 2024. |
MCHR1 antagonist 4
CAS: 1574538-43-4 F: C26H30N2O4 W: 434.53
MCHR1 antagonist 4 (Compound 2m) is a blood-brain barrier permeable MCHR1 antagonist with Ki values of 0.74 nM and 0.76
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