| Bioactivity | MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism[1]. |
| Invitro | Compound 1, derived from a spirohydantoin scaffold, exhibits a Ki of 50 nM at MCH-R1. Compound 1 is a potent inhibitor of CYP3A4 (IC50=35 nM). MCHR1 antagonist 3 is an analog of compound 1[1]. |
| Name | MCHR1 antagonist 3 |
| CAS | 1069622-60-1 |
| Formula | C29H36N4O2 |
| Molar Mass | 472.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rowbottom MW, et al. Synthesis and structure-activity relationships of spirohydantoin-derived small-moleculeantagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Bioorg Med Chem Lett. 2007 Apr 15;17(8):2171-8. |
MCHR1 antagonist 3
CAS: 1069622-60-1 F: C29H36N4O2 W: 472.62
MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is us
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