| Bioactivity | MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC50 of 10 μM. |
| Invitro | MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC50 of 10 μM[1]. |
| In Vivo | MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC0-6 h of 14760 h*ng/mL[1]. |
| Name | MCH-1 antagonist 1 |
| CAS | 1039825-68-7 |
| Formula | C25H26N4O2 |
| Molar Mass | 414.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Henderson AJ, et al. Tetrahydrocarboline analogs as MCH-1 antagonists. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7024-8. |
MCH-1 antagonist 1
CAS: 1039825-68-7 F: C25H26N4O2 W: 414.50
MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a Ki of 2.6 nM. MCH-1 antagonist 1
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