| Bioactivity | MC3138 is a selective SIRT5 activator. MC3138 has antitumor activity on human PDAC cells, with IC50 values of 25.4-236.9 μM. MC3138 combined with Gemcitabine (HY-17026) significantly inhibits tumor growth in mice[1]. |
| Invitro | MC3138 (10 μM, 24 h) 可降低 GOT1 蛋白的赖氨酸乙酰化并抑制其在 PDAC 细胞中的酶活性。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MC3138 相关抗体: |
| CAS | 1844889-12-8 |
| Formula | C25H25NO6 |
| Molar Mass | 435.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hu T, et al. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161(5):1584-1600. |