| Bioactivity | MC2625 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2625 show selective HDAC3 and HDAC6 inhibition with IC50s of 80 nM and 11 nM. MC2625 increases acetyl-H3 and acetyl-tubulin levels and inhibits cancer stem cells (CSCs) growth by apoptosis induction[1][2]. |
| Invitro | MC2625 (0.5-2 μM; 24-72 小时) 在 72 h 后对不同的肉瘤癌症干细胞 (CSCs) 具有有效的抗增殖作用[1]。MC2625 (0.5-2 μM; 48 小时) 显着诱导所有 CSC 培养物的细胞凋亡，A204 CSCs 除外[1]。MC2625 (0.5, 2 μM; 24 小时) 引起乙酰组蛋白 H3 的剂量依赖性增加[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | MC2625 |
| CAS | 1776116-75-6 |
| Formula | C23H21N3O3 |
| Molar Mass | 387.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |