| Bioactivity | MC0704 is a STAT3 inhibitor with an IC50 value of 2.13 μM. MC0704 induces cell apoptosis and cell cycle arrest. MC0704 shows antitumor activity in mouse breast cancer models. MC0704 can be used for the research of metastatic triple-negative breast cancer (mTNBC)[1]. |
| Invitro | MC0704 (0-50 μM；72 h) 对 HEK-293，肺上皮细胞 (MRC-5)，MDA-MB 231，MDA-MB-231 耐紫杉醇 (MDA-MB-231-PTR) 和 MDA-MB-231 耐多西紫杉醇 (MDA-MB-231-DTR) 细胞具有细胞毒性，IC50 值分别为 3.11，33.25，2.98，3.24 和 2.87 μM[1]。MC0704 (0，0.4，2，10 和 50 μM；24 h) 抑制 STAT3 活性，IC50 值为 2.13 μM[1]。MC0704 (5 μM；24 h) 抑制 STAT3 的激活[1]。MC0704 (0，2.5，5 和 10 μM；36-48 h) 增加 MDA-MB-231-DTR 细胞在 G2/M 期的细胞周期阻滞，诱导细胞凋亡[1]。 Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | MC0704 (10 mg/kg，腹腔注射，每日 1 次，12 天) 抑制 MDA-MB-231-DTR 细胞移植小鼠的肿瘤生长[1]。 Animal Model: |
| Name | MC0704 |
| Formula | C29H21BrN4O2 |
| Molar Mass | 537.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Byun WS, et al. Design, Synthesis, and Biological Activity of Marinacarboline Analogues as STAT3 Pathway Inhibitors for Docetaxel-Resistant Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):3106-3133. |