| Bioactivity | MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-13631) with IC50 of 22 μM. MC-Gly-Gly-Phe-Gly-GABA-Exatecan targets various antibodies, exhibits cytotoxic and antitumor efficacy in vitro and in vivo[1][2]. |
| Invitro | MC-Gly-Gly-Phe-Gly-GABA-Exatecan (0-10 μM) 通过靶向 CD30，CD33，CD70 和 B7-H3 抗体，在细胞 SR (CD30 阳性)，HL60 (CD33 阳性)，U251 (CD70 阳性) 和 Calu-6 (B7-H3 阳性) 中表现出细胞毒性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MC-Gly-Gly-Phe-Gly-GABA-Exatecan 相关抗体: Cell Viability Assay[2] Cell Line: |
| In Vivo | MC-Gly-Gly-Phe-Gly-GABA-Exatecan (10 mg/kg，静脉注射，每周一次，共 2 周) 在 A375 异种移植小鼠体内表现出抗肿瘤活性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 1599439-52-7 |
| Formula | C53H58FN9O12 |
| Molar Mass | 1032.08 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Hettmann T, et al., Anti-her3 antibody-drug conjugate. Patent WO2015155998 [2]. Ogitani Y, et al., Wide application of a novel topoisomerase I inhibitor-based drug conjugation technology. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5069-5072. |
MC-Gly-Gly-Phe-Gly-GABA-Exatecan
CAS: 1599439-52-7 F: C53H58FN9O12 W: 1032.08
MC-Gly-Gly-Phe-Gly-GABA-Exatecan is an agent linker conjugate for ADC, with an inhibitor for Topoisomerase Exatecan (HY-
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