Bioactivity | MBP Ac1-9 (4Y) is a synthetic peptide derived from a fragment of myelin basic protein (MBP) that has undergone specific chemical modifications. MBP Ac1-9 (4Y) is able to form a complex with the MHC class II molecule I-Au and activate specific T cell receptor (TCR), thus playing a role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). MBP Ac1-9 (4Y) can be used to study autoimmune diseases, especially those involving the central nervous system, such as multiple sclerosis[1]. |
CAS | 167278-49-1 |
Sequence | Ac-Ala-Ser-Gln-Tyr-Arg-Pro-Ser-Gln-Arg |
Shortening | Ac-ASQYRPSQR |
Formula | C47H75N17O16 |
Molar Mass | 1134.20 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Huang J C, et al. T cell recognition of distinct peptide: I-Au conformers in murine experimental autoimmune encephalomyelitis[J]. The Journal of Immunology, 2003, 171(5): 2467-2477. |