| Bioactivity | MBM-17 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1]. |
| Invitro | MBM-17 (compound 42c) inhibits MGC-803, HCT-116, Bel-7402 cells proliferation with IC50s of 0.48, 1.06, 4.53 μM, respectively[1].MBM-17 (0.25-1.0 μM; 24 hours) induced G2/M phase arrest and accumulation of cells with >4N content[1].MBM-17 (0.5-1.0 μM; 24 hours) triggers apoptosis of cancer cells[1]. Cell Cycle Analysis[1] Cell Line: |
| Name | MBM-17 |
| CAS | 2083621-90-1 |
| Formula | C28H28N6O2 |
| Molar Mass | 480.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
MBM-17
CAS: 2083621-90-1 F: C28H28N6O2 W: 480.56
MBM-17 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferatio
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