| Bioactivity | MB327 is a bipyridine nonoxime compound that restores neuromuscular function. MB327 restores the activity of nicotinamide acetylcholine receptors (nAChRs) for carbachol desensitization in a typical type II PAM manner. MB327 can neutralize nerve agent poisoning[1][2]. |
| Name | MB327 |
| CAS | 61368-98-7 |
| Formula | C21H32I2N2 |
| Molar Mass | 566.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Niessen K V, et al. In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2-and 3-regioisomers[J]. Toxicology Letters, 2018, 293: 190-197. [2]. Seeger T, et al. Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro[J]. Toxicology, 2012, 294(2-3): 80-84. |