| Bioactivity | MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphatase (FBPase) with an IC50 value of 16 nM. | ||||||||||||
| Target | IC50: 16 nM (Human Liver FBPase) | ||||||||||||
| In Vivo | MB06322 (3/6-300 mg/kg (young/aged Zucker diabetic fatty (ZDF) rats); p.o.; once) results in dose-dependent glucose lowering in young ZDF rats with mild diabetes and aged ZDF rats with overt diabetes[1]. Animal Model: | ||||||||||||
| Name | MB05032 | ||||||||||||
| CAS | 261365-11-1 | ||||||||||||
| Formula | C11H15N2O4PS | ||||||||||||
| Molar Mass | 302.29 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Erion MD, et al. MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5. [2]. Zhang Y, et al. Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology. 2010 Oct;151(10):4688-95. |
MB05032
CAS: 261365-11-1 F: C11H15N2O4PS W: 302.29
MB05032 is a special and efficacious gluconeogenesis inhibitor targeted the AMP binding site of fructose 1,6-bisphosphat
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