MAT2A inhibitor 6_product_DataBase

Bioactivity	MAT2A inhibitor 6 (Compound 3N-h) is a specific MAT2A inhibitor with oral activity and yellow fluorescence (IC50=26 nM), capable of visualizing MAT2A both in vitro and in vivo (λex = 430 nm, λem = 585 nm). MAT2A inhibitor 6 can induce apoptosis and has anticancer activity, which can be used in cancer research[1].
Target	IC50: 26 nM (MAT2A).
Invitro	MAT2A inhibitor 6 (Compound 3N-h) (72 h) 显著抑制 HCT-116 (MTAP KO) 细胞的增殖，IC50 值为 0.1 μM，(1 μM; 24 h) 并诱导细胞凋亡 (apoptosis) ( 43% 的细胞处于早期或晚期凋亡)，但对野生型 HCT-116 细胞几乎无毒[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MAT2A inhibitor 6 相关抗体:
In Vivo	MAT2A inhibitor 6 (Compound 3N-h) (50 mg/kg; 灌胃; 一天一次，连续 14 天) 在携带 HCT-116 (MTAP KO) 肿瘤的 Balb/c 小鼠抑制 HCT-116 (MTAP KO) 肿瘤的生长，具有抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2447686-21-5
Formula	C24H19F2N5O3
Molar Mass	463.44
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wang Z, et al. Computer-aided design of a fluorescent MAT2A inhibitor for visualized cancer synthetic lethality. Bioorg Chem. 2024 Sep;150:107582.

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