| Bioactivity | MAT2A-IN-10 (Compound 28) is an orally active MAT2A inhibitor with an IC50 of 26 nM. MAT2A-IN-10 can be used for the research of cancer[1]. |
| Target | IC50: 26 nM (MAT2A) |
| Invitro | MAT2A-IN-10 (Compound 28; 0.1 nM-10 μM; 4 days) 抑制 HCT-116 (MTAP-/-) 细胞增殖，IC50 为 75 ± 5 nM。不抑制 HCT-116 (WT) 细胞增殖[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | MAT2A-IN-10 (Compound 28; p.o.; once daily for 6 days) 在小鼠 HCT-116 (MTAP-/-) 移植模型中导致肿瘤消退[1]。 Animal Model: |
| Name | MAT2A-IN-10 |
| Formula | C27H24F2N6O4 |
| Molar Mass | 534.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang S, et al. Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability. J Med Chem. 2023 Apr 13;66(7):4849-4867. |