| Bioactivity | MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM[1]. | ||||||||||||
| Invitro | MASM7 (1-10 μM, 2 h) increases Mito AR with an EC50 value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN[1].MASM7 (1-1000 μM, 5 min) demonstrates direct binding to the HR2 domain of MFN2 with Kd value of 1.1 μM[1].MASM7 (1 μM, 6 h) does not induce DNA damage in any of the cell lines[1].MASM7 (0-1.5 μM, 72 h) does not decrease cellular viability over the course of 72 h[1].MASM7 (1 μΜ, 6 h) does not induce caspase-3/7 activation in U2OS cells[1]. MASM7 (0-1 μM, 6 h) increases mitochondrial membrane potential in WT MEFs[1]. | ||||||||||||
| Name | MASM7 | ||||||||||||
| CAS | 920868-45-7 | ||||||||||||
| Formula | C22H23N5O2S2 | ||||||||||||
| Molar Mass | 453.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Emmanouil Zacharioudakis, et al. Modulating mitofusins to control mitochondrial function and signaling. Nat Commun. 2022 Jul 7;13(1):3775. |