| Bioactivity | MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 of 1.9±0.5 nM. MAO-B-IN-28 can be used as a candidate for neurodegenerative diseases research[1]. |
| Target | monoamine oxidase B (MAO-B) IC50: 1.9±0.5 nM |
| Invitro | MAO-B-IN-28 (0.5-128 μM, 24 h) 对 MCF-7 细胞有明显的细胞毒作用，而对 MGC-803、HCT-116 和 HepG2 无明显的细胞毒作用。MAO-B-IN-28 (0.5, 4 μM, 24 h) 对分化 SH-SY5Y 细胞和 HVSMC 细胞均无细胞毒性[1]。MAO-B-IN-28 (2, 4 μM, 24 h) 不会引起分化的 SH-SY5Y 细胞内 ROS 水平的增加或造成氧化损伤[1]。 0 --> MAO-B-IN-28 相关抗体: Cell Viability Assay[1] Cell Line: |
| Name | MAO-B-IN-28 |
| Formula | C19H10F3NO4S |
| Molar Mass | 405.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pengbing Mi, et al. Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B). European Journal of Medicinal Chemistry. 2024，263，115956. |