MAO-B-IN-22_product_DataBase

Bioactivity	MAO-B-IN-22 (compound 6h) is a potent MAO-B inhibitor with an IC50 of 0.014 μM. MAO-B-IN-22 has high antioxidant activity, good metal chelating ability, proper BBB permeability and significant neuroprotective effect[1].
Invitro	MAO-B-IN-22 (compound 6h) (2.5-50 μM, 24 h) 可以剂量依赖性的保护过氧化氢诱导的氧化损伤，提高细胞活力[1]。 MAO-B-IN-22 (compound 6h) (0.5-10 μM, 24 h) 可以剂量依赖性的降低 LPS 诱导的 NO 产生，具有抗神经炎症活性[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	MAO-B-IN-22 (compound 6h)(53.5 mg/kg, oral gavage, once a day for 3 weeks) 可以通过抑制 MAO-B 增加多巴胺能神经递质水平和减少 ROS 引起的氧化损伤水平来减轻小鼠的运动损伤，可以减轻 MPTP 治疗小鼠的运动障碍，并可能改善体内 PD 的症状[1]。 Animal Model:
Name	MAO-B-IN-22
CAS	2902600-76-2
Formula	C20H18FNO2
Molar Mass	323.36
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhongcheng Cao, et al. Discovery of novel 2-hydroxyl-4-benzyloxybenzyl aniline derivatives as potential multifunctional agents for the treatment of Parkinson's disease. Eur J Med Chem. 2023 Mar 5;249:115142.

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