| Bioactivity | MAO-B-IN-18 is a potent and selective MAO B inhibitor with IC50s of 52 nM and 14 μM for hMAO B and hMAO A, respectively. MAO-B-IN-18 enables promising cytoprotective effects against hydrogen peroxide insults in neuroblastoma and astrocytes cultures[1]. |
| Invitro | MAO-B-IN-18 (化合物 20; 0.1, 0.5, 1, 5 μM) 在 SH-SY5Y 细胞中，可以通过中等水平的 ROS 清除途径保护神经母细胞瘤细胞免受促氧化损伤[1]。MAO-B-IN-18 (5 μM) 与过氧化氢 (400 μM) 共同孵育，使 DI TNC1 星形胶质细胞系中的活细胞维持在与阳性对照槲皮素 (HY-18085) 在高剂量 (75 μM) 相当的水平[1]。 |
| Name | MAO-B-IN-18 |
| Formula | C25H22N4O5 |
| Molar Mass | 458.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mariagrazia Rullo, et al. Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors. Eur J Med Chem. 2023 Jul 5;255:115352. |